ISIS MER System
The key technology for Microelectrode Recording improving targeting with neurophysiological localisation to assure accuracy and safety in Deep Brain Stimulation procedures.
Neurophysiological Targeting for DBS
The ISIS MER System by inomed Medizintechnik manufactured in India by VCSmed is a compact, powerful platform for intraoperative Microelectrode Recording used in Deep Brain Stimulation surgery and functional neurosurgery procedures.
It enables real-time neurophysiological localisation to improve electrode placement accuracy, minimising risk and optimising surgical outcomes.
Deep Brain Stimulation (DBS) surgery
- Functional neurosurgery - Parkinson's, Dystonia, Tremor
- Intraoperative neuromonitoring (IONM)
- Pain treatment procedures
- Neurological diagnostics and research
5
MER Channels
20kHz
Sampling Rate
16-bit
Resolution
0.1–6mA
Stimulation
Relevant application fields
Functional Neurosurgery
Functional neurosurgery is a specialised branch of neurosurgery that focuses on the diagnosis and treatment of diseases of the central and peripheral nervous system that significantly impair…
System Features:
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Compact Hardware Design
Easy-to-use software and compact hardware guarantee a straightforward intraoperative workflow reducing setup complexity in the OR. -
Optimal Signal Interpretation
Multiple filter options, LFP measurement, and an online TCP/IP interface for streaming raw data (MER, LFP, EMG) and metadata. -
IONM Integration
Combination with IONM modalities offers a wide range of different monitoring possibilities during functional procedures. -
5-Channel MER Recording
ISIS Headbox MER supports 5 simultaneous channels for MER and test stimulation at 20 kHz, 16-bit resolution. -
TCP/IP Raw Data Streaming
NEW: Online TCP/IP interface for real-time streaming of raw MER, LFP, EMG data and metadata including stimulation parameters and impedances. -
FFT/Spike Analysis
Advanced analysis options including FFT, Spike Analysis, and Fire Rate to support comprehensive signal interpretation during surgery.
Benefits/ Features:
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Improved Targeting Accuracy
Neurophysiological localisation through real-time MER signals ensures precise anatomical target point identification, reducing the risk of misplacement during DBS surgery. -
Enhanced Patient Safety
Accurate targeting minimises stimulation of unintended brain structures, reducing adverse effects and improving post-operative outcomes for Parkinson's and Dystonia patients. -
Streamlined OR Workflow
Compact hardware design and intuitive software ensure rapid setup and a straightforward intraoperative workflow, saving valuable surgical time. -
Flexible Monitoring Modalities
Combination with IONM systems expands monitoring capability. LFP recording, EMG, and MER can run simultaneously for comprehensive intraoperative data. -
Advanced Data Connectivity
Online TCP/IP streaming enables integration with hospital IT systems and external analysis tools, supporting research and clinical documentation workflows. -
Modular & Scalable System
Three basic system configurations portable, standard, and advanced allow each centre to equip the ISIS MER System according to their specific clinical and budgetary needs.
Hardware Components
ISIS Headbox Family
Two purpose-built headboxes for recording and stimulation, combinable for LFP measurement across up to 5 channels.
MER Recording - ISIS Headbox MER
Compact hardware base for target point localisation via MER recordings and test stimulation. The essential component for every DBS procedure.
- 5 Channels
- 20 kHz / 16-bit
- TTL Trigger I/O
- 0.1–6mA Stimulation
- 1–300 Hz
- Adjustable Filters
EMG Recording - ISIS Headbox EMG
High-performance system for electromyography offering 8 differential amplifier inputs for simultaneous EMG recording during MER procedures.
- 8 EMG Channels
- 20 kHz / 16-bit
- TTL Trigger I/O
- Adjustable Filters
- Simultaneous with MER
NEW:
Online TCP/IP interface for streaming raw data (MER, LFP, EMG) and metadata including application parameters, impedances, and stimulation data in real time.
MER Accessories
Electrode Designs & Guide Tubes
Three MER electrode designs provide flexibility in adjusting to different target structures in functional neurosurgery.
MicroMacro Electrode
Combined design with ultrafine microtip and ring-shaped macro contact for simultaneous recording of individual cells or whole groups within a single area. Macro contact used for test stimulation.
MicroMove Electrode (iMM)
Combined electrode with a displaceable microtip for single cell recording. The movable microtip guarantees the smallest possible displacement of tissue during functional neurosurgery interventions.
Macro Electrode
Used to determine the anatomical target point by means of selective test stimulation. Mode of action is comparable to that of a DBS electrode — ideal for pre-implant target confirmation.
Frequently Asked Questions
Answers to the most common clinical and technical questions about the ISIS MER System, as asked by neurosurgeons and neuromonitoring teams across India.
What is the ISIS MER System used for in neurosurgery?
The ISIS MER System is the key technology for Microelectrode Recording (MER) in functional neurosurgery. It is primarily used in Deep Brain Stimulation (DBS) procedures for conditions including Parkinson’s disease, essential tremor, and dystonia. The system improves targeting accuracy using neurophysiological localisation, enabling surgeons to identify the precise anatomical target point in real time. It also supports intraoperative neuromonitoring, pain treatment procedures, and neurological diagnostics.
How many channels does the ISIS MER System support?
The ISIS Headbox MER supports 5 channels for simultaneous Microelectrode Recording and test stimulation at 20 kHz with 16-bit resolution. The ISIS Headbox EMG provides 8 differential amplifier inputs for electromyography recording during MER. When both headboxes are combined, local field potential (LFP) measurements are available for up to 5 channels simultaneously.
What electrodes are compatible with the ISIS MER System?
Three electrode types are available: (1) MicroMacro Electrode – simultaneous recording of individual cells and cell groups; (2) MicroMove Electrode (iMM) – displaceable microtip for single cell recording with minimal tissue displacement; (3) Macro Electrode – for selective test stimulation comparable to a DBS electrode. Guide tubes (Universal, MER, and DBS types) in multiple lengths are also available to support the procedure.
Is the ISIS MER System available in India? Yes. The ISIS MER System is manufactured and assembled?
Yes. The ISIS MER System is manufactured and assembled in India by VCSmed India Private Limited, located in Chennai, Tamil Nadu (No. 5, Ariyalur Village, Madhavaram Taluk, Chennai – 600 060). The system is designed and developed by inomed Medizintechnik GmbH, Germany. VCSmed India serves neurosurgery centres across India. Contact VCSmed India at www.vcsmedindia.com for pricing, demonstrations, and support.
What stereotactic frames is the inomed MicroDrive compatible with?
The inomed MicroDrive is adaptable to many stereotactic frames used in functional neurosurgery. It supports simultaneous insertion of up to 5 electrodes via BenGun alignment, provides haptic feedback at 0.5 mm per revolution, and is reusable with a validated processing procedure. Contact VCSmed India or inomed for a specific compatibility list for your centre’s frame.